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Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling
TGF-β is considered a master switch in the pathogenesis of organ fibrosis. The primary mediators of this activity are the SMAD proteins, particularly SMAD3. In the current study, we have developed a cell-penetrating peptide (CPP) conjugate of the HIV TAT protein that is fused to an aminoterminal seq...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5490773/ https://ncbi.nlm.nih.gov/pubmed/28530637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88696 |
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