Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling

TGF-β is considered a master switch in the pathogenesis of organ fibrosis. The primary mediators of this activity are the SMAD proteins, particularly SMAD3. In the current study, we have developed a cell-penetrating peptide (CPP) conjugate of the HIV TAT protein that is fused to an aminoterminal seq...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Kang, Jeong-Han, Jung, Mi-Yeon, Yin, Xueqian, Andrianifahanana, Mahefatiana, Hernandez, Danielle M., Leof, Edward B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490773/
https://ncbi.nlm.nih.gov/pubmed/28530637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88696
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