Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways

TGF-β plays a central role in the pathogenesis of fibroproliferative disorders. Defining the exact underlying molecular basis is therefore critical for the development of viable therapeutic strategies. Here, we show that expression of the facilitative glucose transporter 1 (GLUT1) is induced by TGF-...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Andrianifahanana, Mahefatiana, Hernandez, Danielle M., Yin, Xueqian, Kang, Jeong-Han, Jung, Mi-Yeon, Wang, Youli, Yi, Eunhee S., Roden, Anja C., Limper, Andrew H., Leof, Edward B.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067255/
https://ncbi.nlm.nih.gov/pubmed/27480571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600428R
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