Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways

TGF-β plays a central role in the pathogenesis of fibroproliferative disorders. Defining the exact underlying molecular basis is therefore critical for the development of viable therapeutic strategies. Here, we show that expression of the facilitative glucose transporter 1 (GLUT1) is induced by TGF-...

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Bibliografische gegevens
Gepubliceerd in:FASEB J
Hoofdauteurs: Andrianifahanana, Mahefatiana, Hernandez, Danielle M., Yin, Xueqian, Kang, Jeong-Han, Jung, Mi-Yeon, Wang, Youli, Yi, Eunhee S., Roden, Anja C., Limper, Andrew H., Leof, Edward B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Federation of American Societies for Experimental Biology 2016
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067255/
https://ncbi.nlm.nih.gov/pubmed/27480571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600428R
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