Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease

The absence of effective therapeutics against Alzheimer's disease (AD) is a result of the limited understanding of its multifaceted aetiology. Because of the lack of chemical tools to identify pathological factors, investigations into AD pathogenesis have also been insubstantial. Here we report...

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Publicat a:Nat Commun
Autors principals: Beck, Michael W., Derrick, Jeffrey S., Kerr, Richard A., Oh, Shin Bi, Cho, Woo Jong, Lee, Shin Jung C., Ji, Yonghwan, Han, Jiyeon, Tehrani, Zahra Aliakbar, Suh, Nayoung, Kim, Sujeong, Larsen, Scott D., Kim, Kwang S., Lee, Joo-Yong, Ruotolo, Brandon T., Lim, Mi Hee
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065625/
https://ncbi.nlm.nih.gov/pubmed/27734843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13115
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