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Structure-activity relationships and kinetic studies of peptidic antagonists of CBX chromodomains

To better understand the contribution of methyl-lysine (Kme) binding proteins to various disease states, we recently developed and reported the discovery of 1 (UNC3866), a chemical probe that targets two families of Kme binding proteins, CBX and CDY chromodomains, with selectivity for CBX4 and -7. T...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Med Chem
Κύριοι συγγραφείς: Stuckey, Jacob I., Simpson, Catherine, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Lee, Junghyun, Pasca, Ryan, Cheng, Nancy, Dickson, Bradley M., Pearce, Kenneth H., Frye, Stephen V., James, Lindsey I.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2016
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063714/
https://ncbi.nlm.nih.gov/pubmed/27571219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00801
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