SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage

SOX9 encodes a transcription factor that governs cell fate specification throughout development and tissue homeostasis. Elevated SOX9 is implicated in the genesis and progression of human tumors by increasing cell proliferation and epithelial-mesenchymal transition. We found that in response to UV i...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Hong, Xuehui, Liu, Wenyu, Song, Ruipeng, Shah, Jamie J., Feng, Xing, Tsang, Chi Kwan, Morgan, Katherine M., Bunting, Samuel F., Inuzuka, Hiroyuki, Zheng, X. F. Steven, Shen, Zhiyuan, Sabaawy, Hatem E., Liu, LianXin, Pine, Sharon R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062998/
https://ncbi.nlm.nih.gov/pubmed/27566146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw748
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