Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7

Fbw7 and Cdh1 are substrate-recognition subunits of the SCF- and APC-type E3 ubiquitin ligases, respectively. There is emerging evidence suggesting that both Fbw7 and Cdh1 function as tumor suppressors by targeting oncoproteins for destruction. Loss of Fbw7, but not Cdh1, is frequently observed in v...

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Main Authors: Lau, Alan W, Inuzuka, Hiroyuki, Fukushima, Hidefumi, Wan, Lixin, Liu, Pengda, Gao, Daming, Sun, Yi, Wei, Wenyi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2013
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698637/
https://ncbi.nlm.nih.gov/pubmed/23670162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.67
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