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Differential sensitivity to methylated DNA by ETS-family transcription factors is intrinsically encoded in their DNA-binding domains

Transactivation by the ETS family of transcription factors, whose members share structurally conserved DNA-binding domains, is variably sensitive to methylation of their target genes. The mechanism by which DNA methylation controls ETS proteins remains poorly understood. Uncertainly also pervades th...

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Foilsithe in:Nucleic Acids Res
Main Authors: Stephens, Dominique C., Poon, Gregory M. K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062964/
https://ncbi.nlm.nih.gov/pubmed/27270080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw528
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