An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex

The MBD2-NuRD (Nucleosome Remodeling and Deacetylase) complex is an epigenetic reader of DNA methylation that regulates genes involved in normal development and neoplastic diseases. To delineate the architecture and functional interactions of the MBD2-NuRD complex, we previously solved the structure...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Desai, Megha A., Webb, Heather D., Sinanan, Leander M., Scarsdale, J. Neel, Walavalkar, Ninad M., Ginder, Gordon D., Williams, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381075/
https://ncbi.nlm.nih.gov/pubmed/25753662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv168
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