TAZ and YAP are frequently activated oncoproteins in sarcomas

TAZ (WWTR1) and YAP are transcriptional coactivators and oncoproteins inhibited by the Hippo pathway. Herein we evaluate 159 sarcomas representing the most prevalent sarcoma types by immunohistochemistry for expression and activation (nuclear localization) of TAZ and YAP. We show that 50% of sarcoma...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Fullenkamp, Colleen A., Hall, Sarah L., Jaber, Omar I., Pakalniskis, Brittany L., Savage, Erica C., Savage, Johanna M., Ofori-Amanfo, Georgina K., Lambertz, Allyn M., Ivins, Stephanie D., Stipp, Christopher S., Miller, Benjamin J., Milhem, Mohammed M., Tanas, Munir R.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper: Pathology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058666/
https://ncbi.nlm.nih.gov/pubmed/27129148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8979
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