TAZ and YAP are frequently activated oncoproteins in sarcomas

TAZ (WWTR1) and YAP are transcriptional coactivators and oncoproteins inhibited by the Hippo pathway. Herein we evaluate 159 sarcomas representing the most prevalent sarcoma types by immunohistochemistry for expression and activation (nuclear localization) of TAZ and YAP. We show that 50% of sarcoma...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Fullenkamp, Colleen A., Hall, Sarah L., Jaber, Omar I., Pakalniskis, Brittany L., Savage, Erica C., Savage, Johanna M., Ofori-Amanfo, Georgina K., Lambertz, Allyn M., Ivins, Stephanie D., Stipp, Christopher S., Miller, Benjamin J., Milhem, Mohammed M., Tanas, Munir R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper: Pathology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058666/
https://ncbi.nlm.nih.gov/pubmed/27129148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8979
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