TAZ and YAP are frequently activated oncoproteins in sarcomas

TAZ (WWTR1) and YAP are transcriptional coactivators and oncoproteins inhibited by the Hippo pathway. Herein we evaluate 159 sarcomas representing the most prevalent sarcoma types by immunohistochemistry for expression and activation (nuclear localization) of TAZ and YAP. We show that 50% of sarcoma...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fullenkamp, Colleen A., Hall, Sarah L., Jaber, Omar I., Pakalniskis, Brittany L., Savage, Erica C., Savage, Johanna M., Ofori-Amanfo, Georgina K., Lambertz, Allyn M., Ivins, Stephanie D., Stipp, Christopher S., Miller, Benjamin J., Milhem, Mohammed M., Tanas, Munir R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058666/
https://ncbi.nlm.nih.gov/pubmed/27129148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8979
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