Cancer stem cell drugs target K-ras signaling in a stemness context

Cancer stem cells (CSCs) are considered to be responsible for treatment relapse and have therefore become a major target in cancer research. Salinomycin is the most established CSC inhibitor. However, its primary mechanistic target is still unclear, impeding the discovery of compounds with similar a...

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Detalles Bibliográficos
Publicado en:Oncogene
Autores principales: Najumudeen, A K, Jaiswal, A, Lectez, B, Oetken-Lindholm, C, Guzmán, C, Siljamäki, E, Posada, I M D, Lacey, E, Aittokallio, T, Abankwa, D
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5057041/
https://ncbi.nlm.nih.gov/pubmed/26973241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.59
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