Activation and modulation of recombinant glycine and GABA(A) receptors by 4‐halogenated analogues of propofol

BACKGROUND AND PURPOSE: Glycine receptors are important players in pain perception and movement disorders and therefore important therapeutic targets. Glycine receptors can be modulated by the intravenous anaesthetic propofol (2,6‐diisopropylphenol). However, the drug is more potent, by at least one...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Germann, Allison L, Shin, Daniel J, Manion, Brad D, Edge, Christopher J, Smith, Edward H, Franks, Nicholas P, Evers, Alex S, Akk, Gustav
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056230/
https://ncbi.nlm.nih.gov/pubmed/27459129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13566
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