Robust anti‐nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain

BACKGROUND AND PURPOSE: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain relief. We evaluated the effects of a potent and selec...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Burston, James J, Mapp, Paul I, Sarmad, Sarir, Barrett, David A, Niphakis, Micah J, Cravatt, Benjamin F, Walsh, David A, Chapman, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056226/
https://ncbi.nlm.nih.gov/pubmed/27501482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13574
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