Selective Monoacylglycerol Lipase Inhibitors: Antinociceptive versus Cannabimimetic Effects in Mice

The endogenous cannabinoid 2-arachidonoylglycerol (2-AG) plays an important role in a variety of physiologic processes, but its rapid breakdown by monoacylglycerol lipase (MAGL) results in short-lived actions. Initial MAGL inhibitors were limited by poor selectivity and low potency. In this study, w...

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書目詳細資料
發表在:J Pharmacol Exp Ther
Main Authors: Ignatowska-Jankowska, Bogna, Wilkerson, Jenny L., Mustafa, Mohammed, Abdullah, Rehab, Niphakis, Micah, Wiley, Jenny L., Cravatt, Benjamin F., Lichtman, Aron H.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2015
主題:
Behavioral Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407719/
https://ncbi.nlm.nih.gov/pubmed/25762694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.222315
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