Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice

Inhibition of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL), the primary hydrolytic enzymes for the respective endocannabinoids N-arachidonoylethanolamine (AEA) and 2-arachidonylglycerol (2-AG), produces antinociception but with minimal cannabimimetic side effects. Although sel...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Ghosh, Sudeshna, Kinsey, Steven G., Liu, Qing-song, Hruba, Lenka, McMahon, Lance R., Grim, Travis W., Merritt, Christina R., Wise, Laura E., Abdullah, Rehab A., Selley, Dana E., Sim-Selley, Laura J., Cravatt, Benjamin F., Lichtman, Aron H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Behavioral Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518073/
https://ncbi.nlm.nih.gov/pubmed/25998048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.222851
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