Simultaneous Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Shares Discriminative Stimulus Effects with Δ(9)-Tetrahydrocannabinol in Mice

Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) inhibitors exert preclinical effects indicative of therapeutic potential (i.e., analgesia). However, the extent to which MAGL and FAAH inhibitors produce unwanted effects remains unclear. Here, FAAH and MAGL inhibition was examined...

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Publicat a:J Pharmacol Exp Ther
Autors principals: Hruba, Lenka, Seillier, Alexandre, Zaki, Armia, Cravatt, Benjamin F., Lichtman, Aron H., Giuffrida, Andrea, McMahon, Lance R.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2015
Matèries:
Behavioral Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407717/
https://ncbi.nlm.nih.gov/pubmed/25711338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.222836
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