Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice through Distinct Cannabinoid Receptor Mechanisms

The endocannabinoids, anandamide and 2-arachidonoylglycerol, are predominantly regulated by the respective catabolic enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Inhibition of these enzymes elevates endocannabinoid levels and attenuates neuropathic pain. In the prese...

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Bibliografiset tiedot
Päätekijät: Kinsey, Steven G., Long, Jonathan Z., Cravatt, Benjamin F., Lichtman, Aron H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962430/
https://ncbi.nlm.nih.gov/pubmed/20554481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2010.04.001
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