Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice through Distinct Cannabinoid Receptor Mechanisms

The endocannabinoids, anandamide and 2-arachidonoylglycerol, are predominantly regulated by the respective catabolic enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Inhibition of these enzymes elevates endocannabinoid levels and attenuates neuropathic pain. In the prese...

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Bibliographische Detailangaben
Hauptverfasser: Kinsey, Steven G., Long, Jonathan Z., Cravatt, Benjamin F., Lichtman, Aron H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962430/
https://ncbi.nlm.nih.gov/pubmed/20554481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2010.04.001
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