Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production

Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and pancreatitis. It is endogenously synthesized mainly by two pyridoxal-5′-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ß-synt...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Corvino, Angela, Severino, Beatrice, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Santagada, Vincenzo, Bucci, Mariarosaria, Cirino, Giuseppe, Kelly, Geoff, Servillo, Luigi, Popowicz, Grzegorz, Pastore, Annalisa, Caliendo, Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052628/
https://ncbi.nlm.nih.gov/pubmed/27708394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34398
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