Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents

Two series of N-(aryl)-1-(hydroxyalkyl)pyrrolidine-2-carboxamides (2a–2g and 3a–3g) and 1,4-disubstituted 1,2,3-triazoles (5a–5h and 8a–8h) were synthesized. All the compounds, containing a lipophilic tail and a polar headgroup, were evaluated as sphingosine kinase (SphK) inhibitors by assessing the...

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Foilsithe in:Int J Mol Sci
Main Authors: Corvino, Angela, Rosa, Roberta, Incisivo, Giuseppina Maria, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Saccone, Irene, Santagada, Vincenzo, Cirino, Giuseppe, Riemma, Maria Antonietta, Temussi, Piero A., Ciciola, Paola, Bianco, Roberto, Caliendo, Giuseppe, Roviezzo, Fiorentina, Severino, Beatrice
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713301/
https://ncbi.nlm.nih.gov/pubmed/29113071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18112332
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