Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents

Two series of N-(aryl)-1-(hydroxyalkyl)pyrrolidine-2-carboxamides (2a–2g and 3a–3g) and 1,4-disubstituted 1,2,3-triazoles (5a–5h and 8a–8h) were synthesized. All the compounds, containing a lipophilic tail and a polar headgroup, were evaluated as sphingosine kinase (SphK) inhibitors by assessing the...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Corvino, Angela, Rosa, Roberta, Incisivo, Giuseppina Maria, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Saccone, Irene, Santagada, Vincenzo, Cirino, Giuseppe, Riemma, Maria Antonietta, Temussi, Piero A., Ciciola, Paola, Bianco, Roberto, Caliendo, Giuseppe, Roviezzo, Fiorentina, Severino, Beatrice
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713301/
https://ncbi.nlm.nih.gov/pubmed/29113071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18112332
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