Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents

Two series of N-(aryl)-1-(hydroxyalkyl)pyrrolidine-2-carboxamides (2a–2g and 3a–3g) and 1,4-disubstituted 1,2,3-triazoles (5a–5h and 8a–8h) were synthesized. All the compounds, containing a lipophilic tail and a polar headgroup, were evaluated as sphingosine kinase (SphK) inhibitors by assessing the...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Corvino, Angela, Rosa, Roberta, Incisivo, Giuseppina Maria, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Saccone, Irene, Santagada, Vincenzo, Cirino, Giuseppe, Riemma, Maria Antonietta, Temussi, Piero A., Ciciola, Paola, Bianco, Roberto, Caliendo, Giuseppe, Roviezzo, Fiorentina, Severino, Beatrice
Format: Artigo
Langue:Inglês
Publié: MDPI 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713301/
https://ncbi.nlm.nih.gov/pubmed/29113071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18112332
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