Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production

Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and pancreatitis. It is endogenously synthesized mainly by two pyridoxal-5′-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ß-synt...

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Publicado no:Sci Rep
Main Authors: Corvino, Angela, Severino, Beatrice, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Santagada, Vincenzo, Bucci, Mariarosaria, Cirino, Giuseppe, Kelly, Geoff, Servillo, Luigi, Popowicz, Grzegorz, Pastore, Annalisa, Caliendo, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052628/
https://ncbi.nlm.nih.gov/pubmed/27708394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34398
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