Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production

Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and pancreatitis. It is endogenously synthesized mainly by two pyridoxal-5′-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ß-synt...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Corvino, Angela, Severino, Beatrice, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Santagada, Vincenzo, Bucci, Mariarosaria, Cirino, Giuseppe, Kelly, Geoff, Servillo, Luigi, Popowicz, Grzegorz, Pastore, Annalisa, Caliendo, Giuseppe
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052628/
https://ncbi.nlm.nih.gov/pubmed/27708394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34398
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