mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

Follicular helper T (Tfh) cells are crucial for germinal center (GC)formation andhumoraladaptiveimmunity. Mechanisms underlying Tfh cell differentiation in peripheral and mucosal lymphoid organs are incompletely understood. We report here that mTOR kinase complexes 1 and 2 (mTORC1 and mTORC2) are es...

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Publicado en:Immunity
Main Authors: Zeng, Hu, Cohen, Sivan, Guy, Cliff, Shrestha, Sharad, Neale, Geoffrey, Brown, Scott A., Cloer, Caryn, Kishton, Rigel J., Gao, Xia, Youngblood, Ben, Do, Mytrang, Li, Ming O., Locasale, Jason W., Rathmell, Jeffrey C., Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050556/
https://ncbi.nlm.nih.gov/pubmed/27637146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.08.017
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