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Regulatory T cells require the phosphatase PTEN to restrain type 1 and follicular helper T-cell responses
The interplay between effector and regulatory T (T(reg)) cells is crucial for adaptive immunity, but how T(reg) control diverse effector responses is elusive. We found that the phosphatase PTEN links T(reg) stability to repression of T(H)1 and T(FH) (follicular helper) responses. Depletion of PTEN i...
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| Pubblicato in: | Nat Immunol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297581/ https://ncbi.nlm.nih.gov/pubmed/25559258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3076 |
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