S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and regulatory T cells

Por Liu, Guangwei, Yang, Kai, Burns, Samir, Shrestha, Sharad, Chi, Hongbo
Publicado em 2010

Regulatory T cells require the phosphatase PTEN to restrain type 1 and follicular helper T-cell responses

Por Shrestha, Sharad, Yang, Kai, Guy, Cliff, Vogel, Peter, Neale, Geoffrey, Chi, Hongbo
Publicado no Nat Immunol (2015)

Tsc1 promotes the differentiation of memory CD8(+) T cells via orchestrating the transcriptional and metabolic programs

Por Shrestha, Sharad, Yang, Kai, Wei, Jun, Karmaus, Peer W. F., Neale, Geoffrey, Chi, Hongbo
Publicado em 2014

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic programming

Por Yang, Kai, Shrestha, Sharad, Zeng, Hu, Karmaus, Peer W.F., Neale, Geoffrey, Vogel, Peter, Guertin, David A., Lamb, Richard F., Chi, Hongbo
Publicado em 2013

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

Por Wei, Jun, Long, Lingyun, Yang, Kai, Guy, Cliff, Shrestha, Sharad, Chen, Zuojia, Wu, Chuan, Vogel, Peter, Neale, Geoffrey, Green, Douglas R, Chi, Hongbo
Publicado no Nat Immunol (2016)

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation

Por Nguyen, Hung D., Chatterjee, Shilpak, Haarberg, Kelley M.K., Wu, Yongxia, Bastian, David, Heinrichs, Jessica, Fu, Jianing, Daenthanasanmak, Anusara, Schutt, Steven, Shrestha, Sharad, Liu, Chen, Wang, Honglin, Chi, Hongbo, Mehrotra, Shikhar, Yu, Xue-Zhong
Publicado no J Clin Invest (2016)

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

Por Zeng, Hu, Cohen, Sivan, Guy, Cliff, Shrestha, Sharad, Neale, Geoffrey, Brown, Scott A., Cloer, Caryn, Kishton, Rigel J., Gao, Xia, Youngblood, Ben, Do, Mytrang, Li, Ming O., Locasale, Jason W., Rathmell, Jeffrey C., Chi, Hongbo
Publicado no Immunity (2016)