Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7–driven B lymphopoiesis

Interleukin-7 (IL-7) drives early B lymphopoiesis, but the underlying molecular circuits remain poorly understood, especially how Stat5 (signal transducer and activator of transcription 5)–dependent and Stat5-independent pathways contribute to this process. Combining transcriptome and proteome analy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Adv
Prif Awduron: Zeng, Hu, Yu, Mei, Tan, Haiyan, Li, Yuxin, Su, Wei, Shi, Hao, Dhungana, Yogesh, Guy, Cliff, Neale, Geoffrey, Cloer, Caryn, Peng, Junmin, Wang, Demin, Chi, Hongbo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Association for the Advancement of Science 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792226/
https://ncbi.nlm.nih.gov/pubmed/29399633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar5701
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