Amino acids license kinase mTORC1 activity and Treg cell function via small G proteins Rag and Rheb

Regulatory T (Treg) cells are critical mediators of immune tolerance whose activity depends upon T cell receptor (TCR) and mTORC1 kinase signaling, but the mechanisms that dictate functional activation of these pathways are incompletely understood. Here, we showed that amino acids license Treg cell...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunity
Prif Awduron: Shi, Hao, Chapman, Nicole M., Wen, Jing, Guy, Cliff, Long, Lingyun, Dhungana, Yogesh, Rankin, Sherri, Pelletier, Stephane, Vogel, Peter, Wang, Hong, Peng, Junmin, Guan, Kun-Liang, Chi, Hongbo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948188/
https://ncbi.nlm.nih.gov/pubmed/31668641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.10.001
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