Amino acids license kinase mTORC1 activity and Treg cell function via small G proteins Rag and Rheb

Regulatory T (Treg) cells are critical mediators of immune tolerance whose activity depends upon T cell receptor (TCR) and mTORC1 kinase signaling, but the mechanisms that dictate functional activation of these pathways are incompletely understood. Here, we showed that amino acids license Treg cell...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Shi, Hao, Chapman, Nicole M., Wen, Jing, Guy, Cliff, Long, Lingyun, Dhungana, Yogesh, Rankin, Sherri, Pelletier, Stephane, Vogel, Peter, Wang, Hong, Peng, Junmin, Guan, Kun-Liang, Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948188/
https://ncbi.nlm.nih.gov/pubmed/31668641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.10.001
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