Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF–mediated myelopoiesis

Myelopoiesis is necessary for the generation of mature myeloid cells during homeostatic turnover and immunological insults; however, the metabolic requirements for this process remain poorly defined. Here, we demonstrate that myelopoiesis, including monocyte and macrophage differentiation, requires...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Karmaus, Peer W.F., Herrada, Andrés A., Guy, Cliff, Neale, Geoffrey, Dhungana, Yogesh, Long, Lingyun, Vogel, Peter, Avila, Julian, Clish, Clary B., Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584119/
https://ncbi.nlm.nih.gov/pubmed/28784627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161855
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