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Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC

We describe a convergent synthesis of a bryostatin analogue in which the natural A- and B-ring pyrans have been replaced by phenyl rings. The new analogue exhibited PMA like behavior in cell assays, but failed to maintain high affinity binding for PKC, despite retaining an unaltered C-ring ‘binding...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Tetrahedron Lett
Egile Nagusiak: Petersen, Mark E., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M., Keck, Gary E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5047013/
https://ncbi.nlm.nih.gov/pubmed/27713589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2016.09.040
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