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Synthetic Studies on the Bryostatins: Preparation of a Truncated BC-Ring Intermediate by Pyran Annulation
[Image: see text] A synthesis of a potential BC-ring subunit (C(9)–C(27)) for bryostatin 1, a remarkably potent anticancer agent, has been developed in 16 steps and 18% overall yield. The key features of this route include a BITIP-catalyzed asymmetric allylation reaction, chelation-controlled allyla...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1480406/ https://ncbi.nlm.nih.gov/pubmed/15901156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol050511w |
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