Efficacy and safety evaluation of claudin‐4‐targeted antitumor therapy using a human and mouse cross‐reactive monoclonal antibody

Claudin‐4 (CLDN‐4), a tight‐junction protein, is overexpressed in various malignant tumors, including gastric, colorectal, pancreatic, and breast cancers. However, CLDN‐4 is also expressed in normal tissues, including the liver, pancreas, kidney, and small intestine. Whether CLDN‐4 is an effective a...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Hashimoto, Yosuke, Kawahigashi, Yumi, Hata, Tomoyuki, Li, Xiangru, Watari, Akihiro, Tada, Minoru, Ishii‐Watabe, Akiko, Okada, Yoshiaki, Doi, Takefumi, Fukasawa, Masayoshi, Kuniyasu, Hiroki, Yagi, Kiyohito, Kondoh, Masuo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045943/
https://ncbi.nlm.nih.gov/pubmed/27713828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.266
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