Efficacy and safety evaluation of claudin‐4‐targeted antitumor therapy using a human and mouse cross‐reactive monoclonal antibody

Claudin‐4 (CLDN‐4), a tight‐junction protein, is overexpressed in various malignant tumors, including gastric, colorectal, pancreatic, and breast cancers. However, CLDN‐4 is also expressed in normal tissues, including the liver, pancreas, kidney, and small intestine. Whether CLDN‐4 is an effective a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharmacol Res Perspect
Prif Awduron: Hashimoto, Yosuke, Kawahigashi, Yumi, Hata, Tomoyuki, Li, Xiangru, Watari, Akihiro, Tada, Minoru, Ishii‐Watabe, Akiko, Okada, Yoshiaki, Doi, Takefumi, Fukasawa, Masayoshi, Kuniyasu, Hiroki, Yagi, Kiyohito, Kondoh, Masuo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045943/
https://ncbi.nlm.nih.gov/pubmed/27713828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.266
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