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Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5

The production of antibodies against the extracellular regions (ECR) of multispanning membrane proteins is notoriously difficult because of the low productivity and immunogenicity of membrane proteins due to their complex structure and highly conserved sequences among species. Here, we introduce a n...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hashimoto, Yosuke, Zhou, Wei, Hamauchi, Kohtaroh, Shirakura, Keisuke, Doi, Takefumi, Yagi, Kiyohito, Sawasaki, Tatsuya, Okada, Yoshiaki, Kondoh, Masuo, Takeda, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976803/
https://ncbi.nlm.nih.gov/pubmed/29849184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26560-9
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