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Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5

The production of antibodies against the extracellular regions (ECR) of multispanning membrane proteins is notoriously difficult because of the low productivity and immunogenicity of membrane proteins due to their complex structure and highly conserved sequences among species. Here, we introduce a n...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Hashimoto, Yosuke, Zhou, Wei, Hamauchi, Kohtaroh, Shirakura, Keisuke, Doi, Takefumi, Yagi, Kiyohito, Sawasaki, Tatsuya, Okada, Yoshiaki, Kondoh, Masuo, Takeda, Hiroyuki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976803/
https://ncbi.nlm.nih.gov/pubmed/29849184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26560-9
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