Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay

Claudins are key functional and structural components of tight junctions (TJs) in epithelial cell sheets. The C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) binds to claudin-4 and reversibly modulates intestinal TJ seals, thereby enhancing paracellular transport of solutes. Howev...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Watari, Akihiro, Kodaka, Miki, Matsuhisa, Koji, Sakamoto, Yuta, Hisaie, Kota, Kawashita, Norihito, Takagi, Tatsuya, Yamagishi, Yoshiaki, Suzuki, Hidehiko, Tsujino, Hirofumi, Yagi, Kiyohito, Kondoh, Masuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674027/
https://ncbi.nlm.nih.gov/pubmed/29109448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15108-y
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