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Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression

Several stressors are known to influence epithelial tight junction (TJ) integrity, but the association between DNA damage and TJ integrity remains unclear. Here we examined the effects of daunorubicin and rebeccamycin, two anti-tumor chemicals that induce DNA damage, on TJ integrity in human intesti...

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Pubblicato in:PLoS One
Autori principali: Watari, Akihiro, Hasegawa, Maki, Yagi, Kiyohito, Kondoh, Masuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699696/
https://ncbi.nlm.nih.gov/pubmed/26727128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145631
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