Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

Hepatitis C virus (HCV) entry into host cells is a complex process requiring multiple host factors, including claudin-1 (CLDN1). Safe and effective therapeutic entry inhibitors need to be developed. We isolated a human hepatic Huh7.5.1-derived cell mutant that is nonpermissive to HCV, and comparativ...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Fukasawa, Masayoshi, Nagase, Shotaro, Shirasago, Yoshitaka, Iida, Manami, Yamashita, Mayo, Endo, Kohki, Yagi, Kiyohito, Suzuki, Tetsuro, Wakita, Takaji, Hanada, Kentaro, Kuniyasu, Hiroki, Kondoh, Masuo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403477/
https://ncbi.nlm.nih.gov/pubmed/25673725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03676-14
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