Targeting Cellular Squalene Synthase, an Enzyme Essential for Cholesterol Biosynthesis, Is a Potential Antiviral Strategy against Hepatitis C Virus

Hepatitis C virus (HCV) exploits host membrane cholesterol and its metabolism for progeny virus production. Here, we examined the impact of targeting cellular squalene synthase (SQS), the first committed enzyme for cholesterol biosynthesis, on HCV production. By using the HCV JFH-1 strain and human...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Saito, Kyoko, Shirasago, Yoshitaka, Suzuki, Tetsuro, Aizaki, Hideki, Hanada, Kentaro, Wakita, Takaji, Nishijima, Masahiro, Fukasawa, Masayoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338862/
https://ncbi.nlm.nih.gov/pubmed/25473062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03385-14
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