Targeting Cellular Squalene Synthase, an Enzyme Essential for Cholesterol Biosynthesis, Is a Potential Antiviral Strategy against Hepatitis C Virus

Hepatitis C virus (HCV) exploits host membrane cholesterol and its metabolism for progeny virus production. Here, we examined the impact of targeting cellular squalene synthase (SQS), the first committed enzyme for cholesterol biosynthesis, on HCV production. By using the HCV JFH-1 strain and human...

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Vydáno v:J Virol
Hlavní autoři: Saito, Kyoko, Shirasago, Yoshitaka, Suzuki, Tetsuro, Aizaki, Hideki, Hanada, Kentaro, Wakita, Takaji, Nishijima, Masahiro, Fukasawa, Masayoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338862/
https://ncbi.nlm.nih.gov/pubmed/25473062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03385-14
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