Targeting Cellular Squalene Synthase, an Enzyme Essential for Cholesterol Biosynthesis, Is a Potential Antiviral Strategy against Hepatitis C Virus

Hepatitis C virus (HCV) exploits host membrane cholesterol and its metabolism for progeny virus production. Here, we examined the impact of targeting cellular squalene synthase (SQS), the first committed enzyme for cholesterol biosynthesis, on HCV production. By using the HCV JFH-1 strain and human...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Saito, Kyoko, Shirasago, Yoshitaka, Suzuki, Tetsuro, Aizaki, Hideki, Hanada, Kentaro, Wakita, Takaji, Nishijima, Masahiro, Fukasawa, Masayoshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338862/
https://ncbi.nlm.nih.gov/pubmed/25473062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03385-14
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