Targeting Cellular Squalene Synthase, an Enzyme Essential for Cholesterol Biosynthesis, Is a Potential Antiviral Strategy against Hepatitis C Virus

Hepatitis C virus (HCV) exploits host membrane cholesterol and its metabolism for progeny virus production. Here, we examined the impact of targeting cellular squalene synthase (SQS), the first committed enzyme for cholesterol biosynthesis, on HCV production. By using the HCV JFH-1 strain and human...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Saito, Kyoko, Shirasago, Yoshitaka, Suzuki, Tetsuro, Aizaki, Hideki, Hanada, Kentaro, Wakita, Takaji, Nishijima, Masahiro, Fukasawa, Masayoshi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338862/
https://ncbi.nlm.nih.gov/pubmed/25473062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03385-14
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