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A brief history of the discovery of PXR and CAR as xenobiotic receptors
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998. Due to their activities in the transcriptional regulation of phase I and phase II enzymes as well as drug transporters, PXR and CAR have been def...
Guardat en:
| Publicat a: | Acta Pharm Sin B |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5045536/ https://ncbi.nlm.nih.gov/pubmed/27709013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2016.06.011 |
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