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A brief history of the discovery of PXR and CAR as xenobiotic receptors

The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were cloned and/or established as xenobiotic receptors in 1998. Due to their activities in the transcriptional regulation of phase I and phase II enzymes as well as drug transporters, PXR and CAR have been def...

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Dettagli Bibliografici
Pubblicato in:Acta Pharm Sin B
Autori principali: Yan, Jiong, Xie, Wen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045536/
https://ncbi.nlm.nih.gov/pubmed/27709013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2016.06.011
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