Targeting Xenobiotic Nuclear Receptors PXR and CAR to Prevent Cobicistat Hepatotoxicity

Liver-related diseases including drug-induced liver injury are becoming increasingly prominent in AIDS patients. Cobicistat (COBI) is the backbone of multiple regimens for antiretroviral therapy. The current work investigated the mechanisms of adverse drug-drug interactions associated with COBI that...

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Vydáno v:Toxicol Sci
Hlavní autoři: Shehu, Amina I, Zhu, Junjie, Li, Jianhua, Lu, Jie, McMahon, Deborah, Xie, Wen, Gonzalez, Frank J, Ma, Xiaochao
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Clinical and Translational Toxicology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081023/
https://ncbi.nlm.nih.gov/pubmed/33629115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfab023
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