Pregnane X receptor activation potentiates ritonavir hepatotoxicity

Ritonavir (RTV) is on the World Health Organization’s list of essential medicines for antiretroviral therapy, but can cause hepatotoxicity by unknown mechanisms. Multiple clinical studies found that hepatotoxicity occurred in 100% of participants who were pretreated with rifampicin or efavirenz foll...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Clin Invest
Hlavní autoři: Shehu, Amina I., Lu, Jie, Wang, Pengcheng, Zhu, Junjie, Wang, Yue, Yang, Da, McMahon, Deborah, Xie, Wen, Gonzalez, Frank J., Ma, Xiaochao
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Concise Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597219/
https://ncbi.nlm.nih.gov/pubmed/31039134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128274
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky