Pregnane X receptor activation potentiates ritonavir hepatotoxicity

Ritonavir (RTV) is on the World Health Organization’s list of essential medicines for antiretroviral therapy, but can cause hepatotoxicity by unknown mechanisms. Multiple clinical studies found that hepatotoxicity occurred in 100% of participants who were pretreated with rifampicin or efavirenz foll...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Shehu, Amina I., Lu, Jie, Wang, Pengcheng, Zhu, Junjie, Wang, Yue, Yang, Da, McMahon, Deborah, Xie, Wen, Gonzalez, Frank J., Ma, Xiaochao
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Concise Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597219/
https://ncbi.nlm.nih.gov/pubmed/31039134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128274
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