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Pregnane X receptor activation potentiates ritonavir hepatotoxicity
Ritonavir (RTV) is on the World Health Organization’s list of essential medicines for antiretroviral therapy, but can cause hepatotoxicity by unknown mechanisms. Multiple clinical studies found that hepatotoxicity occurred in 100% of participants who were pretreated with rifampicin or efavirenz foll...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6597219/ https://ncbi.nlm.nih.gov/pubmed/31039134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128274 |
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