Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

The kinesin-8 motor, KIF19A, accumulates at cilia tips and controls cilium length. Defective KIF19A leads to hydrocephalus and female infertility because of abnormally elongated cilia. Uniquely among kinesins, KIF19A possesses the dual functions of motility along ciliary microtubules and depolymeriz...

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Vydáno v:eLife
Hlavní autoři: Wang, Doudou, Nitta, Ryo, Morikawa, Manatsu, Yajima, Hiroaki, Inoue, Shigeyuki, Shigematsu, Hideki, Kikkawa, Masahide, Hirokawa, Nobutaka
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045296/
https://ncbi.nlm.nih.gov/pubmed/27690357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18101
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