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Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
The kinesin-8 motor, KIF19A, accumulates at cilia tips and controls cilium length. Defective KIF19A leads to hydrocephalus and female infertility because of abnormally elongated cilia. Uniquely among kinesins, KIF19A possesses the dual functions of motility along ciliary microtubules and depolymeriz...
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| Veröffentlicht in: | eLife |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5045296/ https://ncbi.nlm.nih.gov/pubmed/27690357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18101 |
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